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1

Polychlorinated Biphenyls (PCBs), Dibenzo-p-Dioxins (PCDDs), Dibenzofurans (PCDFs), and Related Compounds: Environmental and Mechanistic Considerations Which Support the Development of Toxic Equivalency Factors (TEFs)

Journal:

Critical Reviews in Toxicology

Year:

1990

Language:

english

File:

PDF, 3.70 MB

english, 1990

2

High-resolution PCB analysis: synthesis and chromatographic properties of all 209 PCB congeners

Mullins, Michael D., Pochini, Cynthia M., McCrindle, Shelia., Romkes, Marjorie., Safe, Stephen H., Safe, Lorna M.

Journal:

Environmental Science & Technology

Year:

1984

Language:

english

File:

PDF, 922 KB

english, 1984

3

Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of miRNA-27a and miRNA-155 in cell survival and inflammation

Nivedita Banerjee, Stephen Talcott, Stephen Safe, Susanne U. Mertens-Talcott

Journal:

Breast Cancer Research and Treatment

Year:

2012

Language:

english

File:

PDF, 944 KB

english, 2012

4

INTERACTIONS BETWEEN HORMONES AND CHEMICALS IN BREAST CANCER

Safe, Stephen H.

Journal:

Annual Review of Pharmacology

Year:

1998

Language:

english

File:

PDF, 311 KB

english, 1998

5

Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β

Kuiper, George G. J. M., Lemmen, Josephine G., Carlsson, Bo, Corton, J. Christopher, Safe, Stephen H., van der Saag, Paul T., van der Burg, Bart, Gustafsson, Jan-Åke

Journal:

Year:

1998

Language:

english

File:

PDF, 342 KB

english, 1998

6

Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-dependent kinase (AMPK)

Draz, Hossam, Goldberg, Alexander A., Titorenko, Vladimir I., Guns, Emma, Safe, Stephen H., Sanderson, J. Thomas

Journal:

Cellular Signalling

Year:

2017

Language:

english

File:

PDF, 2.18 MB

english, 2017

7

Toxicology of persistent organic pollutants

Stephen H. Safe, Stephen H. Safe

Journal:

European Journal of Lipid Science and Technology

Year:

2000

Language:

english

File:

PDF, 16 KB

english, 2000

8

Sp transcription factor family and its role in cancer

Stephen Safe, Maen Abdelrahim

Journal:

European Journal of Cancer

Year:

2005

Language:

english

File:

PDF, 289 KB

english, 2005

9

Comparative Potencies of Aroclors 1232, 1242, 1248, 1254, and 1260 in Male Wistar Rats—Assessment of the Toxic Equivalency Factor (TEF) Approach for Polychlorinated Biphenyls (PCBs)

HARRIS, MARK, ZACHAREWSKI, TIM, SAFE, STEPHEN

Journal:

Toxicological Sciences

Year:

1993

Language:

english

File:

PDF, 704 KB

english, 1993

10

Specificity Protein Transcription Factors and Cancer: Opportunities for Drug Development

Safe, Stephen, Abbruzzese, James L., Abdelrahim, Maen, Hedrick, Erik

Journal:

Cancer Prevention Research

Year:

2018

Language:

english

File:

PDF, 2.85 MB

english, 2018

11

Chemoprevention of Skin Cancer with 1,1-Bis (3′-Indolyl)-1-(Aromatic) Methane Analog through Induction of the Orphan Nuclear Receptor, NR4A2 (Nurr1)

Boakye, Cedar H. A., Doddapaneni, Ravi, Shah, Punit P., Patel, Apurva R., Godugu, Chandraiah, Safe, Stephen, Katiyar, Santosh K., Singh, Mandip, Dahiya, Rajvir

Journal:

Year:

2013

Language:

english

File:

PDF, 974 KB

english, 2013

12

Environmental Estrogens: Roles in Male Reproductive Tract Problems and in Breast Cancer

Journal:

Reviews on Environmental Health

Year:

2002

Language:

english

File:

PDF, 1.21 MB

english, 2002

13

Polychlorinated Biphenyls (PCBs): Environmental Impact, Biochemical and Toxic Responses, and Implications for Risk Assessment

Safe, Stephen H.

Journal:

Critical Reviews in Toxicology

Year:

1994

Language:

english

File:

PDF, 5.47 MB

english, 1994

14

Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives

Gayathri Chadalapaka, Indira Jutooru, Alan McAlees, Tom Stefanac, Stephen Safe

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 164 KB

english, 2008

15

Differential activation of wild-type and variant forms of estrogen receptor α by synthetic and natural estrogenic compounds using a promoter containing three estrogen-responsive elements

Kyungsil Yoon, Lea Pallaroni, Matthew Stoner, Kevin Gaido, Stephen Safe

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2001

Language:

english

File:

PDF, 201 KB

english, 2001

16

Absorption and Biological Activity of Phytochemical-Rich Extracts from Açai (Euterpe oleracea Mart.) Pulp and Oil in Vitro

Pacheco-Palencia, Lisbeth A., Talcott, Stephen T., Safe, Stephen, Mertens-Talcott, Susanne

Journal:

Journal of Agricultural and Food Chemistry

Year:

2008

Language:

english

File:

PDF, 367 KB

english, 2008

17

Xenoestrogens and Breast Cancer

Safe, Stephen H.

Journal:

Boston Medical and Surgical Journal

Year:

1997

Language:

english

File:

PDF, 127 KB

english, 1997

18

Unifying Mechanisms of Action of the Anticancer Activities of Triterpenoids and Synthetic Analogs

H. Safe, Stephen, L. Prather, Paul, K. Brents, Lisa, Chadalapaka, Gayathri, Jutooru, Indira

Journal:

Anti-Cancer Agents in Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 997 KB

english, 2012

19

Toxicological significance of non-, mono- and di-ortho-substituted polychlorinated biphenyls in oysters from galveston and tampa bays

Jose L. Sericano, Terry L. Wade, James M. Brooks, Stephen H. Safe

Journal:

Environmental Toxicology and Chemistry

Year:

1994

Language:

english

File:

PDF, 559 KB

english, 1994

20

Cancer chemotherapy with indole-3-carbinol, bis(3′-indolyl)methane and synthetic analogs

Stephen Safe, Sabitha Papineni, Sudhakar Chintharlapalli

Journal:

Year:

2008

Language:

english

File:

PDF, 218 KB

english, 2008

21

Do environmental estrogens play a role in development of breast cancer in women and male reproductive problems?

Safe, Stephen H.

Journal:

Human and Ecological Risk Assessment An International Journal

Year:

1995

Language:

english

File:

PDF, 433 KB

english, 1995

22

Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: Role of Sp transcription factors and microRNA-27a:ZBTB10

Susanne U. Mertens-Talcott, Giuliana D. Noratto, Xiangrong Li, Gabriela Angel-Morales, Michele C. Bertoldi, Stephen Safe

Journal:

Molecular Carcinogenesis

Year:

2012

Language:

english

File:

PDF, 550 KB

english, 2012

23

Comparative Potencies of Aroclors 1232, 1242, 1248, 1254, and 1260 in Male Wistar Rats—Assessment of the Toxic Equivalency Factor (TEF) Approach for Polychlorinated Biphenyls (PCBs)

Mark Harris, Tim Zacharewski, Stephen Safe

Journal:

Fundamental and Applied Toxicology

Year:

1993

File:

PDF, 461 KB

1993

24

Limitations of the toxic equivalency factor approach for risk assessment of TCDD and related compounds

Journal:

Teratogenesis, Carcinogenesis, and Mutagenesis

Year:

1997

Language:

english

File:

PDF, 98 KB

english, 1997

25

Reactive Oxygen Species (ROS)-inducing Triterpenoid Inhibits Rhabdomyosarcoma Cell and Tumor Growth through Targeting Sp Transcription Factors

Kasiappan, Ravi, Jutooru, Indira, Mohankumar, Kumaravel, Karki, Keshav, Lacey, Alexandra, Safe, Stephen

Journal:

Molecular Cancer Research

Year:

2019

Language:

english

File:

PDF, 5.18 MB

english, 2019

26

Naringenin: A weakly estrogenic bioflavonoid that exhibits antiestrogenic activity

Mary F. Ruh, Timothy Zacharewski, Kevin Connor, James Howell, Ichen Chen, Stephen Safe

Journal:

Biochemical Pharmacology

Year:

1995

Language:

english

File:

PDF, 1.27 MB

english, 1995

27

Polychlorinated Biphenyls (PCBs) and Polybrominated Biphenyls (PBBs): Biochemistry, Toxicology, and Mechanism of Action

Safe, Stephen, Hutzinger, Otto

Journal:

Critical Reviews in Toxicology

Year:

1984

Language:

english

File:

PDF, 4.51 MB

english, 1984

28

Pharmacologic Doses of Ascorbic Acid Repress Specificity Protein (Sp) Transcription Factors and Sp-Regulated Genes in Colon Cancer Cells

Pathi, Satya S., Lei, Ping, Sreevalsan, Sandeep, Chadalapaka, Gayathri, Jutooru, Indira, Safe, Stephen

Journal:

Nutrition and Cancer

Year:

2011

Language:

english

File:

PDF, 560 KB

english, 2011

29

Peroxisome proliferator-activated receptor γ-dependent activity of indole ring-substituted 1,1-bis(3′-indolyl)-1-(p-biphenyl)methanes in cancer cells

Jingjing Guo, Sudhakar Chintharlapalli, Syng-ook Lee, Sung Dae Cho, Ping Lei, Sabitha Papineni, Stephen Safe

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2010

Language:

english

File:

PDF, 543 KB

english, 2010

30

Effects of Developmental Exposure to Indole-3-carbinol or 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Reproductive Potential of Male Rat Offspring

Clynn Wilker, Larry Johnson, Stephen Safe

Journal:

Toxicology and Applied Pharmacology

Year:

1996

Language:

english

File:

PDF, 183 KB

english, 1996

31

Crosstalk between estrogen receptor α and the aryl hydrocarbon receptor in breast cancer cells involves unidirectional activation of proteasomes

Mark Wormke, Matthew Stoner, Brad Saville, Stephen Safe

Journal:

Year:

2000

Language:

english

File:

PDF, 293 KB

english, 2000

32

[3H]-Tetrachlorodibenzo-p-dioxin: An efficient photoaffinity label for the Ah receptor

James P. Landers, Stephen H. Safe, Nigel J. Bunce

Journal:

Year:

1990

Language:

english

File:

PDF, 385 KB

english, 1990

33

Corrigenda

Fujita, Eiichi, Uchida, Itsuo, Fujita, Tetsuro, Masaki, Norio, Osaka, Kenji, Przybylska, Maria, Gopalakrishna, Ellur M., Taylor, Alan, Safe, Stephen, Fenton, D. E., Nave, C., Truter, Mary R.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1974

Language:

english

File:

PDF, 55 KB

english, 1974

34

Modulation of rat hepatic microsomal testosterone hydroxylases by 2,3,7,8-tetrachlorodibenzo- p -dioxin and related toxic isostereomers

Keys, Barbara, Hlavinka, Michelle, Mason, Grant, Safe, Stephen

Journal:

Canadian Journal of Physiology and Pharmacology

Year:

1985

Language:

english

File:

PDF, 650 KB

english, 1985

35

Inhibition of 3,3′,4,4′,5-Pentachlorobiphenyl-Induced Chicken Embryotoxicity by 2,2′,4,4′,5,5′-Hexachlorobiphenyl

ZHAO, FENG, MAYURA, KITTANE, KOCUREK, NATHAN, EDWARDS, JOHN F., KUBENA, LEON F., SAFE, STEPHEN H., PHILLIPS, TIMOTHY D.

Journal:

Toxicological Sciences

Year:

1997

Language:

english

File:

PDF, 1.50 MB

english, 1997

36

10.1071/RD00108

Safe, Stephen H., Pallaroni, Lea, Yoon, Kyungsil, Gaido, Kevin, Ross, Susan, Saville, Brad, McDonnell, Donald

Journal:

Reproduction Fertility and Development

Year:

2001

Language:

english

File:

PDF, 140 KB

english, 2001

37

A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro

Hammond, Sean L., Safe, Stephen, Tjalkens, Ronald B.

Journal:

Neuroscience Letters

Year:

2015

Language:

english

File:

PDF, 909 KB

english, 2015

38

Transcriptional Activation of Thymidylate Synthase by 17β-Estradiol in MCF-7 Human Breast Cancer Cells 1

Xie, Wen, Duan, Reqin, Chen, Ichen, Samudio, Ismael, Safe, Stephen

Journal:

Year:

2000

Language:

english

File:

PDF, 396 KB

english, 2000

39

NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration

Hedrick, Erik, Lee, Syng-Ook, Doddapaneni, Ravi, Singh, Mandip, Safe, Stephen

Journal:

Molecular and Cellular Biology

Year:

2016

Language:

english

File:

PDF, 2.48 MB

english, 2016

40

MP45-02 CDODA-ME DECREASES SPECIFICITY PROTEIN TRANSCRIPTION FACTORS AND INDUCES APOPTOSIS IN BLADDER CANCER CELLS THROUGH INDUCTION OF REACTIVE OXYGEN SPECIES

Takeuchi, Hisashi, Taoka, Rikiya, Jinesh, Goodwin G, Mmeje, Chinedu O, Safe, Stephen, Aoyagi, Teiichiro, Tachibana, Masaaki, Kamat, Ashish M

Journal:

The Journal of Urology

Year:

2016

Language:

english

File:

PDF, 409 KB

english, 2016

41

The p38 MAPK pathway is critical for 5,5′-dibromodiindolylmethane-induced apoptosis to prevent oral squamous carcinoma cells

Choi, Kyeong-Hee, Kim, Hyung-Kook, Kim, Jun-Hee, Choi, Eun-Sun, Shin, Ji-Ae, Lee, Syng-Ook, Chintharlapalli, Sudhakar, Safe, Stephen, Abdelrahim, Maen, Kong, Gu, Choi, Hong Seok, Jung, Ji-Youn, Cho, H

Journal:

European Journal of Cancer Prevention

Year:

2010

Language:

english

File:

PDF, 401 KB

english, 2010

42

Natural Products as Mechanism-based Anticancer Agents: Sp Transcription Factors as Targets

Safe, Stephen, Kasiappan, Ravi

Journal:

Phytotherapy Research

Year:

2016

Language:

english

File:

PDF, 308 KB

english, 2016

43

Problems for Risk Assessment of Endocrine-Active Estrogenic Compounds

Safe, Stephen H., Pallaroni, Lea, Yoon, Kyungsil, Gaido, Kevin, Ross, Susan, McDonnell, Donald

Journal:

Environmental Health Perspectives

Year:

2002

Language:

english

File:

PDF, 155 KB

english, 2002

44

Interleukin-24 (IL-24) Is Suppressed By PAX3-FOXO1 and Is A Novel Therapy For Rhabdomyosarcoma

Lacey, Alexandra, Hedrick, Erik, Cheng, Yating, Mohankumar, Kumaravel, Warren, Melanie, Safe, Stephen

Journal:

Molecular Cancer Therapeutics

Year:

2018

Language:

english

File:

PDF, 1.40 MB

english, 2018

45

Comparative kinetic study of the binding between 2,3,7,8-tetrachlorodibenzo-ρ-dioxin and related ligands with the hepatic Ah receptors from several rodent species

Jamie S. Nakai, Martha J. Winhall, Nigel J. Bunce, Rhonda Rosengren, Stephen Safe

Journal:

Journal of Biochemical and Molecular Toxicology

Year:

1994

Language:

english

File:

PDF, 973 KB

english, 1994

46

Development of gel staining techniques for detecting the secretion of procathepsin D (52-kDa protein) in MCF-7 human breast cancer cells

Venkatesh Krishnan, Tumkur Narasimhan, Stephen Safe

Journal:

Analytical Biochemistry

Year:

1992

Language:

english

File:

PDF, 1.01 MB

english, 1992

47

Differential time course of induction of rat liver microsomal cytochrome P-450 isozymes and epoxide hydrolase by Aroclor 1254

Andrew Parkinson, Paul E. Thomas, Dene E. Ryan, Linda M. Reik, Stephen H. Safe, Larry W. Robertson, Wayne Levin

Journal:

Archives of Biochemistry and Biophysics

Year:

1983

Language:

english

File:

PDF, 1.13 MB

english, 1983

48

2,3,7,8-tetrachlorodibenzo-p-dioxin as an antiestrogen: Effect on rat uterine peroxidase activity

Barry Astroff, Stephen Safe

Journal:

Biochemical Pharmacology

Year:

1990

Language:

english

File:

PDF, 474 KB

english, 1990

49

Cytochrome P-450-mediated metabolism of biphenyl and the 4-halobiphenyls

Andrew Parkinson, Stephen Safe

Journal:

Biochemical Pharmacology

Year:

1982

Language:

english

File:

PDF, 832 KB

english, 1982

50

Metabolism of chlorinated naphthalenes

Ruzo, Luis, Jones, Dan, Safe, Stephen, Hutzinger, Otto

Journal:

Journal of Agricultural and Food Chemistry

Year:

1976

Language:

english

File:

PDF, 382 KB

english, 1976

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